No foci of pathologic uptake due to prostate cancer relapse were detected. A 64-year-old patient examined for restaging prostate cancer after radical prostatectomy undergone 68Ga-PSMA PET/CT the patient was previously submitted (2 years before the scan) to surgical excision of glioblastoma in the left occipital lobe and ipsilateral cerebellar lobe consequently, a further PET/CT of the brain was performed. Similar results are also known for a variant of PSMA, labeled with 64Cu ( Calabria et al., 2019).įor these reasons, a lack of specificity in the brain is also known for this tracer caution and the correlative approach with MRI should be of the utmost importance in order to correctly identify a 68Ga-PSMA-avid lesion in the brain.įig. To date, is known the possibility to detect 68Ga-PSMA uptake in lesions as melanoma metastases ( Hod et al., 2020), cerebral tuberculosis ( Wong et al., 2020), and also rare but not uncommon brain metastases of prostate cancer ( Chan et al., 2017).
NETSPOT PET SERIES
PSMA is the acronym for Prostate-Specific Membrane Antigen and presents a low gradient of uptake in the brain: despite the term “ specific,” since their first use, it has emerged an extensive series of benign and malignant conditions, generally as reports of a case, demonstrating 68Ga-PSMA uptake in the brain, not linked to prostate cancer. Orazio Schillaci, in Reference Module in Biomedical Sciences, 2021 68Ga-PSMAĦ8Ga-PSMA is a more recent tracer, useful in detecting prostate cancer recurrence in patients with biochemical relapse, earlier than radiolabeled choline. slice-overlap artifact a.k.a.Agostino Chiaravalloti.propylene glycol peak: resonates at 1.13 ppm.N-acetylaspartate (NAA) peak: resonates at 2.0 ppm.glutamine-glutamate peak: resonates at 2.2-2.4 ppm.gamma-aminobutyric acid (GABA) peak: resonates at 2.2-2.4 ppm.
2-hydroxyglutarate peak: resonates at 2.25 ppm.arterial spin labeling (ASL) MR perfusion.dynamic contrast enhanced (DCE) MR perfusion.dynamic susceptibility contrast (DSC) MR perfusion.metal artifact reduction sequence (MARS).turbo inversion recovery magnitude (TIRM).fluid attenuation inversion recovery (FLAIR).
diffusion tensor imaging and fiber tractography.MRI pulse sequences ( basics | abbreviations | parameters).iodinated contrast-induced thyrotoxicosis.iodinated contrast media adverse reactions.clinical applications of dual-energy CT.as low as reasonably achievable (ALARA).(2015) Radiographics : a review publication of the Radiological Society of North America, Inc. Somatostatin receptor imaging with 68Ga DOTATATE PET/CT: clinical utility, normal patterns, pearls, and pitfalls in interpretation. Physiological and tumoral uptake of (68)Ga-DOTATATE: standardized uptake values and challenges in interpretation. Kuyumcu S, Özkan ZG, Sanli Y, Yilmaz E, Mudun A, Adalet I, Unal S. Neuroendocrine Tumor Diagnosis and Management: Ga-DOTATATE PET/CT. Sanli Y, Garg I, Kandathil A, Kendi T, Zanetti MJB, Kuyumcu S, Subramaniam RM. (2007) European journal of nuclear medicine and molecular imaging. Are radiogallium-labelled DOTA-conjugated somatostatin analogues superior to those labelled with other radiometals?. Antunes P, Ginj M, Zhang H, Waser B, Baum RP, Reubi JC, Maecke H. (2016) Journal of nuclear medicine : official publication, Society of Nuclear Medicine. Safety and Efficacy of 68Ga-DOTATATE PET/CT for Diagnosis, Staging, and Treatment Management of Neuroendocrine Tumors. Deppen SA, Liu E, Blume JD, Clanton J, Shi C, Jones-Jackson LB, Lakhani V, Baum RP, Berlin J, Smith GT, Graham M, Sandler MP, Delbeke D, Walker RC. The salivary glands and thyroid show faint to mild homogeneous uptake 4,5. There is normal Ga-68 DOTATATE uptake in the pituitary gland, spleen, liver, adrenal glands, and urinary tract 4,5. These have an affinity for different somatostatin receptors, SSTR subtypes 3 and 5 and SSTR subtype 5, respectively 3. It binds SSTR subtype 2 and binds 100 times more avidly than indium-111 pentetreotide 2. Ga-68 DOTATATE has shown improved accuracy for detection relative to indium-111 pentetreotide SPECT-CT 1. to the short-chain peptide Tyr3-octreotate (TATE).linked, via a chemical macrocyclic chelator, known as DOTA (or tetraxetan IUPAC name: 1,4,7,10-tetraazacyclododecane-tetraacetic acid).Gallium-68 DOTATATE is synthesized from three main components: